H2N2V1, 1968, Analysis, bibRecord, 000001

The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

Identifieur interne : 000001 ( 1968/Analysis ); précédent : 000000; suivant : 000002

The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

Auteurs : Hongquan Wan [États-Unis] ; Jin Gao [États-Unis] ; Hua Yang [États-Unis] ; Shuang Yang [États-Unis] ; Ruth Harvey [Royaume-Uni] ; Yao-Qing Chen [États-Unis] ; Nai-Ying Zheng [États-Unis] ; Jessie Chang [États-Unis] ; Paul J. Carney [États-Unis] ; Xing Li [États-Unis] ; Ewan Plant [États-Unis] ; Lianlian Jiang [États-Unis] ; Laura Couzens [États-Unis] ; Carol Wang [États-Unis] ; Shirin Strohmeier [États-Unis] ; Wells W. Wu [États-Unis] ; Rong-Fong Shen [États-Unis] ; Florian Krammer [États-Unis] ; John F. Cipollo [États-Unis] ; Patrick C. Wilson [États-Unis] ; James Stevens [États-Unis] ; Xiu-Feng Wan [États-Unis] ; Maryna C. Eichelberger [États-Unis] ; Zhiping Ye [États-Unis]

Source :

Nature microbiology [ 2058-5276 ] ; 2019.

RBID : PMC:6879794

Abstract

The predominance of A(H3N2) virus in recent influenza seasons has resulted in rigorous investigation on hemagglutinin, but little attention has been paid to the potential role of neuraminidase (NA). Here we show that since 2016, the S245N/S247T (introducing an N-linked glycosylation site at residue 245) and P468H mutations contributed to antigenic drift of the NA of circulating A(H3N2) viruses, compared with earlier viruses represented by the A/Hong Kong/4801/2014 vaccine strain. As a result, some human monoclonal antibodies, including those that have broad-reactivity with NA of the reference 1957 A(H2N2) and 1968 A(H3N2) pandemic viruses as well as contemporary seasonal A(H3N2) strains, lost binding to NA. This antigenic drift also reduced NA antibody-based protection against in vivo virus challenge. X-ray crystallography showed that the NA245 glycosylation site is within a conserved epitope that overlaps the NA active site, explaining why it impacts antibody binding. Our findings suggest that NA antigenic drift may impact protection against influenza virus infection, highlighting the importance of including NA antigenicity for consideration in optimizing influenza vaccines.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879794

DOI: 10.1038/s41564-019-0522-6
PubMed: 31406333
PubMed Central: 6879794

Affiliations:

Links to Exploration step

PMC:6879794

Le document en format XML

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</author>
<author><name sortKey="Chang, Jessie" sort="Chang, Jessie" uniqKey="Chang J" first="Jessie" last="Chang">Jessie Chang</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carney, Paul J" sort="Carney, Paul J" uniqKey="Carney P" first="Paul J." last="Carney">Paul J. Carney</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xing" sort="Li, Xing" uniqKey="Li X" first="Xing" last="Li">Xing Li</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plant, Ewan" sort="Plant, Ewan" uniqKey="Plant E" first="Ewan" last="Plant">Ewan Plant</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Lianlian" sort="Jiang, Lianlian" uniqKey="Jiang L" first="Lianlian" last="Jiang">Lianlian Jiang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Couzens, Laura" sort="Couzens, Laura" uniqKey="Couzens L" first="Laura" last="Couzens">Laura Couzens</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Division of Biological Standards and Quantity Control, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biological Standards and Quantity Control, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Carol" sort="Wang, Carol" uniqKey="Wang C" first="Carol" last="Wang">Carol Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strohmeier, Shirin" sort="Strohmeier, Shirin" uniqKey="Strohmeier S" first="Shirin" last="Strohmeier">Shirin Strohmeier</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Wells W" sort="Wu, Wells W" uniqKey="Wu W" first="Wells W." last="Wu">Wells W. Wu</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shen, Rong Fong" sort="Shen, Rong Fong" uniqKey="Shen R" first="Rong-Fong" last="Shen">Rong-Fong Shen</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cipollo, John F" sort="Cipollo, John F" uniqKey="Cipollo J" first="John F." last="Cipollo">John F. Cipollo</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea>
<placeName><region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
</placeName>
<orgName type="university">Université de Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39762, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39762</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Division of Biological Standards and Quantity Control, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biological Standards and Quantity Control, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ye, Zhiping" sort="Ye, Zhiping" uniqKey="Ye Z" first="Zhiping" last="Ye">Zhiping Ye</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature microbiology</title>
<idno type="eISSN">2058-5276</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P3">The predominance of A(H3N2) virus in recent influenza seasons has resulted in rigorous investigation on hemagglutinin, but little attention has been paid to the potential role of neuraminidase (NA). Here we show that since 2016, the S245N/S247T (introducing an <italic>N</italic>
-linked glycosylation site at residue 245) and P468H mutations contributed to antigenic drift of the NA of circulating A(H3N2) viruses, compared with earlier viruses represented by the A/Hong Kong/4801/2014 vaccine strain. As a result, some human monoclonal antibodies, including those that have broad-reactivity with NA of the reference 1957 A(H2N2) and 1968 A(H3N2) pandemic viruses as well as contemporary seasonal A(H3N2) strains, lost binding to NA. This antigenic drift also reduced NA antibody-based protection against <italic>in vivo</italic>
 virus challenge. X-ray crystallography showed that the NA245 glycosylation site is within a conserved epitope that overlaps the NA active site, explaining why it impacts antibody binding. Our findings suggest that NA antigenic drift may impact protection against influenza virus infection, highlighting the importance of including NA antigenicity for consideration in optimizing influenza vaccines.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
<li>Illinois</li>
<li>Maryland</li>
<li>État de New York</li>
<li>État du Mississippi</li>
</region>
<settlement><li>Chicago</li>
</settlement>
<orgName><li>Université de Chicago</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Wan, Hongquan" sort="Wan, Hongquan" uniqKey="Wan H" first="Hongquan" last="Wan">Hongquan Wan</name>
</region>
<name sortKey="Carney, Paul J" sort="Carney, Paul J" uniqKey="Carney P" first="Paul J." last="Carney">Paul J. Carney</name>
<name sortKey="Chang, Jessie" sort="Chang, Jessie" uniqKey="Chang J" first="Jessie" last="Chang">Jessie Chang</name>
<name sortKey="Chen, Yao Qing" sort="Chen, Yao Qing" uniqKey="Chen Y" first="Yao-Qing" last="Chen">Yao-Qing Chen</name>
<name sortKey="Cipollo, John F" sort="Cipollo, John F" uniqKey="Cipollo J" first="John F." last="Cipollo">John F. Cipollo</name>
<name sortKey="Couzens, Laura" sort="Couzens, Laura" uniqKey="Couzens L" first="Laura" last="Couzens">Laura Couzens</name>
<name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name>
<name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name>
<name sortKey="Jiang, Lianlian" sort="Jiang, Lianlian" uniqKey="Jiang L" first="Lianlian" last="Jiang">Lianlian Jiang</name>
<name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name>
<name sortKey="Li, Xing" sort="Li, Xing" uniqKey="Li X" first="Xing" last="Li">Xing Li</name>
<name sortKey="Plant, Ewan" sort="Plant, Ewan" uniqKey="Plant E" first="Ewan" last="Plant">Ewan Plant</name>
<name sortKey="Shen, Rong Fong" sort="Shen, Rong Fong" uniqKey="Shen R" first="Rong-Fong" last="Shen">Rong-Fong Shen</name>
<name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name>
<name sortKey="Strohmeier, Shirin" sort="Strohmeier, Shirin" uniqKey="Strohmeier S" first="Shirin" last="Strohmeier">Shirin Strohmeier</name>
<name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name>
<name sortKey="Wang, Carol" sort="Wang, Carol" uniqKey="Wang C" first="Carol" last="Wang">Carol Wang</name>
<name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name>
<name sortKey="Wu, Wells W" sort="Wu, Wells W" uniqKey="Wu W" first="Wells W." last="Wu">Wells W. Wu</name>
<name sortKey="Yang, Hua" sort="Yang, Hua" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name>
<name sortKey="Yang, Shuang" sort="Yang, Shuang" uniqKey="Yang S" first="Shuang" last="Yang">Shuang Yang</name>
<name sortKey="Ye, Zhiping" sort="Ye, Zhiping" uniqKey="Ye Z" first="Zhiping" last="Ye">Zhiping Ye</name>
<name sortKey="Zheng, Nai Ying" sort="Zheng, Nai Ying" uniqKey="Zheng N" first="Nai-Ying" last="Zheng">Nai-Ying Zheng</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Harvey, Ruth" sort="Harvey, Ruth" uniqKey="Harvey R" first="Ruth" last="Harvey">Ruth Harvey</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Sante
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   |texte=   The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain
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The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

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